The Theory of Constraints (TOC), from Eliyahu Goldratt, holds that any system's output is limited by a single constraint, so the fastest path to improvement is to focus there. Its five focusing steps are: identify, exploit, subordinate everything else to, elevate the constraint, then repeat.
TOC schedules production with Drum-Buffer-Rope and projects with critical chain. Its central lesson: improving a non-constraint adds cost without adding throughput.